Venky Pingali

Venky Pingali

Position: Instrument Scientist

Beamline: CG-3

Instrument: Biological Small-Angle Neutron Scattering Instrument

Group: Energy and the Environment

Facility: High Flux Isotope Reactor


Phone: (865) 241-2424

2011- Research Staff Scientist and Bio-SANS Beamline Scientist, Biology and Soft Matter Division, Oak Ridge National Laboratory, Oak Ridge TN

2010-2011 Postdoctoral Research Associate, Neutron Scattering Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN

2008-2010 Postdoctoral Research Associate, Chemical Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN

2005-2008 Postdoctoral Fellow, Intense Pulsed Neutron Source Facility, Argonne National Laboratory, Argonne, IL


1998-2005 Ph.D (Physics), University of Illinois at Chicago, Chicago, IL

1996-1998 M.Sc (Physics), University of Hyderabad, Hyderabad, INDIA

1992-1995 B.Sc Hons (Physics), Sri Sathya Sai Institute of Higher Learning, Bangalore, INDIA


​Structural studies of biochemical and chemical systems that address critical questions in the fields of Bioenergy/Biofuels, Biomedicine and Advanced Materials.

Selected Publications

  1. Heller, W.T., Urban, V.S., Lynn, G.W., Weiss, K.L., O’Neill, H.M., Pingali, S.V., Qian, S., Littrell, K.C., Melnichenko, Y.B., Buchanan, M.V., Selby, D.L., Wignall, G.D., Butler, P.D., and Myles, D.A. (2014) The Bio-SANS Instrument at the High Flux Isotope Reactor of Oak Ridge National Laboratory. Journal of Applied Crystallography, 47(4), 1238-1246.
  2. Kim, M.D., Dergunov, S.A., Richter, A.G., Durbin, J., Shmakov, S.N., Jia, Y., Kenbeilova, S., Orazbekuly, Y., Kengpeiil, A., Lindner, E., Pingali, S.V., Urban, V.S., Weigand, S., and Pinkhassik, E. (2014) Facile Directed Assembly of Hollow Polymer Nanocapsules within Spontaneously Formed Catanionic Surfactant Vesicles. Langmuir, 30(24), 7061-7069.
  3. Wang, H., Gurau, G., Pingali, S.V., O’Neill, H.M., Evans, B.R., Urban, V., Heller W.T., and Rogers, R.D. (2014), Physical Insight into Switchgrass Dissolution in Ionic Liquid 1-Ethyle-3-methylimidazolium Acetate. ACS Sustainable Chemistry & Engineering, 2(5), 1264-1269.
  4. Pingali, S.V., O’Neill, H.M., Nishiyama, Y., He, L.L., Melnichenko, Y.B., Urban, V. Petridis, L., Davison, B., and Langan, P. (2014), Morphological Changes in the Cellulose and Lignin Components of Biomass Occur at Different Stages Steam Pretreatment. Cellulose, 21(2), 873-878 (SI).
  5. Mansoorabadi, S.O., Wu, M.L., Tao, Z.H., Gao, P., Pingali, S.V., Guo, L., and Liu, H.W. (2014), Conformational Activation of Poly(ADP-ribose) Polymerase-1 upon DNA Binding Revealed by Small-Angle X-ray Scattering. Biochemistry, 53(11), 1779–1788.
  6. Langan, P., Petridis, L., O’Neill, H.M., Pingali, S.V., Foston, M., Nishiyama, Y., Schulz, R., Lindner, B., Hanson, B.L., Harton, S., Heller, W.T., Urban, V., Evans, B.R., Gnanakaran, S., Ragauskas, A.J., Smith, J.C., and Davison, B.H. (2014), Common Processes Drive the Thermochemical Pretreatment of Lignocellulosic Biomass. Green Chemistry, 16(1), 63–68.
  7. Tang, J.K-H., Saikin, S.K., Pingali, S.V., Enriquez, M.M., Huh, J., Frank, H.A., Urban, V.S. and Aspuru-Guzik, A. (2013) Temperature and Carbon Assimilation Regulate the Chlorosome Biogenesis in Green Sulfur Bacteria. Biophysical Journal, 105 (6), 1346-1356.
  8. Dergunov, S.A., Richter, A.G., Kim, M.D., Pingali, S.V., Urban, V.S. and Pinkhassik, E. (2013) Synergistic self-assembly of scaffolds and building blocks of directed synthesis of organic nanomaterials. Chemical Communication, 49(94), 11026-11028.
  9. Berry, K.D., Bailey, K.M., Beal, J., Diawara, Y., Funk, L., Hicks, J.S., Jones, A.B., Littrell, K.C., Pingali, S.V., Summers, P.R., Urban, V.S., Vandergriff, D.H., Johnson, N.H. and Bradley, B.J. (2012) Characterization of the Neutron Detector Upgrade to the GP-SANS and Bio-SANS Instruments at HFIR. Nuclear Instruments & Methods in Physics Research Section A, 693, 179–185.
  10. Harton, S.E., Pingali, S.V., Nunnery, G.A., Baker, D., Walker, S.H., Muddiman, D.C., Koga, T., Urban, V.S. and Langan, P. (2012), Evidence for Complex Architectures for Solvent-Extracted Lignins. ACS Macro Letters, 1(5), 568–573.
  11. Tekobo, S., Richter, A.G., Dergunov, S.A., Pingali, S.V., Urban, V.S., Yan, B. and Pinkhassik, E. (2011) Synthesis, characterization, and controlled aggregation of biotemplated polystyrene nanodisks. Journal of Nanoparticle Research, 13(12), 6427-6437.
  12. Pingali, S.V., O’Neill, H.M., McGaughey, J., Urban, V.S., Myles, D.A.A., Petridis, L., Smith, J.C., Evans, B.R. and Heller, W.T. (2011) Small-angle neutron scattering reveals pH-dependent conformational changes in Trichoderma reesei cellobiohydrolase I: Implications of enzymatic activity. Journal of Biological Chemistry, 286(37), 32801–32809.
  13. Wang, J., Lu, H., Kamat, R., Pingali, S.V., Urban, V.S., Cheng, J. and Lin, Y. (2011) Supramolecular Polymerization from Polypeptide-Grafted Comb Polymers. Journal of American Chemical Society, 133(33), 12906–12909.
  14. Petridis, L., Pingali, S.V., Urban, V.S., Heller, W.T., O’Neill, H.M., Foston, M., Ragauskas, A. and Smith, J.C. (2011) Self-similar multscale structure of Lignin Aggregates revealed by neutron scattering and molecular dynamic simulation. Physical Review E., 83(6), 061911.
  15. Richter, A.G., Dergunov, S.A., Ganus, B., Thomas, Z., Pingali, S.V., Urban, V.S., Liu, Y., Porcar, L. and Pinkhassik, E. (2011) Scattering studies of hydrophobic monomers in liposomal bilayers: an expanding shell model of monomer distribution. Langmuir, 27(7), 3792–3797.
  16. Pingali, S.V., Urban, V.S., Heller, W.T., McGaughey, J., O’Neill, H.M., Foston, M., Myles, D.A.A., Ragauskas, A. and Evans, B.R. (2010) SANS study of cellulose extracted from switchgrass. Acta Crystallographica Section D., D66, 1189–1193.
  17. Pingali, S.V., Urban, V.S., Heller, W.T., McGaughey, J., O’Neill, H.M., Foston, M., Myles, D.A.A., Ragauskas, A. and Evans, B.R. (2010) Breakdown of cell wall nanostructure in dilute acid pretreated biomass. Biomacromolecules, 11(9), 2329–2335.
  18. Kaur, G., He, J.B., Xu, J., Pingali, S.V., Jutz, G., Boker, A., Niu, Z.W., Li, T., Rawlinson, D., Emrick, T., Lee, B., Thiyagarajan, P., Russell, T.P. and Wang, Q. (2009) Interfacial assembly of turnip yellow mosaic virus nanoparticles. Langmuir, 25(9), 5168–5176.
  19. Mehta, A.K., Lu, K., Childers, W.S., Liang, Y., Dublin, S.N., Dong, J.J., Snyder, J.P., Pingali, S.V., Thiyagarajan, P. and Lynn, D.G. (2008) Facial symmetry in protein self-assembly. Journal of American Chemical Society, 130(30), 9829–9835.
  20. Liang, Y., Pingali, S.V., Jogalekar, A.S., Snyder, J.P., Thiyagarajan, P. and Lynn, D.G. (2008) Cross-strand pairing and amyloid assembly. Biochemistry, 47(38), 10018–10026.

Awards, Honors and Memberships

2012 SEA Award for Leading role in HFIR SANS Detector Upgrade Project, Oak Ridge National Laboratory, Oak Ridge TN

1998 Ranked in Top-5 in M.Sc. (Physics), University of Hyderabad, India

1995 Ranked in Top-5 in B.Sc. Hons (Physics), Sri Sathya Sai Institute of Higher Learning, India