Mayank Aggarwal

Position: Clifford G. Shull Fellow

Facility: Spallation Neutron Source

Email: aggarwalm@ornl.gov

- Graduate Mentor and Research Assistant (2010 – 2013) University of Florida , FL (USA).

- Teaching Assistant (Fall 2011) University of Florida, FL (USA).

- Research Assistant (2008 – 2009) South Carolina Center for Biotechnology, SC (USA).

- Teaching Assistant (2007 – 2008) Claflin University, SC (USA).

Education

- Ph.D. in Biomedical Sciences (2013) from the Department of Biochemistry and Molecular Biology at the College of Medicine, University of Florida, Gainesville, FL.

- M.S. in Biotechnology (2009) from the Department of Biology, Claflin University, Orangeburg, SC.

- B.Tech. in Biotechnology (2007) from Jaypee Institute of Information Technology University, NOIDA, India

Research

- Isoform Specific Drug Design Targeting Human and Prokaryotic Carbonic Anhydrases, uing Neutron Diffraction

- Understand the Underlying Bases and Features that Impart Thermostablity to Proteins

Selected Publications

Aggarwal M, Kondeti B, Chingkuang Tu, Maupin CM, Silverman DN, and McKenna R; Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles; IUCrJ; 2014 Mar; 1: 129-35.

Aggarwal M, Kovalevsky AY, Silverman DN, McKenna R, and Fisher SZ; Neutron protein crystallography reveals unique details of clinical drug binding to a human target enzyme; Neutron News; 2013 Oct; 24(4): 20-23.

Aggarwal M, Kondeti B, and McKenna R; Anti-convulsant/Anti-epileptic carbonic anhydrase inhibitors: A patent review; Expert Opin Ther Pat.; 2013 May; 23(6): 717-24.

Aggarwal M, Boone CD, Kondeti B, Tu CK, Silverman DN, and McKenna R; Effects of cryoprotectants on the structure and thermostability of human carbonic anhydrase II – acetazolamide complex; Acta Crystallogr D Biol Crystallogr.; 2013 May; 69(Pt.): 860-5.

Aggarwal M, Boone CD, Kondeti B, and McKenna R; Structural annotation of human carbonic anhydrases. J Enzyme Inhib Med Chem; 2013 Apr; 28(2): 267-77.

Aggarwal M, Kondeti B, and McKenna R; Insights towards sulfonamide drug specificity in alpha carbonic anhydrases; Bioorg Med Chem.; 2013 Mar; 21(6): 15256-33.

Fisher SZ, Aggarwal M, Kovalevsky AY, Silverman DN, and McKenna R; Neutron diffraction of acetazolamide-bound human carbonic anhydrase II reveals atomic details of drug binding; JACS; 2012 Sep; 134(36): 14726-9.

Aggarwal M, McKenna R; Update on carbonic anhydrase inhibitors: A patent review (2008 – 2011); Expert Opin Ther Pat.; 2012 July; 22(8): 903-15.

Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Masini E, Supuran CT; Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo; J Med Chem. 2012 Feb; 55(4): 1721-30.

Carta F, Aggarwal M, Maresca A, Scozzafava A, McKenna R, Supuran CT; Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations; Chem Commun (Camb). 2012 Feb; 48(13): 1868-70.

Biswas S, Aggarwal M, Güzel O, Scozzafava A, McKenna R, Supuran CT; Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms; Bioorg Med Chem. 2011 Jun; 19(12): 3732-8.

Pacchiano F, Aggarwal M, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, and Supuran CT; Selective hydrophobic pocket binding observed within the carbonic anhydrase II active site accommodate different 4-substituted-ureido-benzenesulfonamides and correlate to inhibitor potency; Chem. Commun. (Camb). 2010 Nov; 46(44): 8371-3.